Transcriptomics

Dataset Information

40

Transcription profiling of human fibroblast isolated from either back or forearm punch biopsies from normal control patients, patients with a diagnosis of Systemic Sclerosis with Diffuse Scleroderma and patients with a diagnosis of morphea


ABSTRACT: Fibroblast were isolated from either back or forearm punch biopsies taken by Dr. Kari Connolly(UCSF) from either normal control patients, patients with a diagnosis of Systemic Sclerosis with Diffuse Scleroderma and patients with a diagnosis of morphea. Scleroderma fibroblast were grown to confluence, media was changed and the RNA prepared from the cells 48 hrs later (to avoid serum responsive genes).

ORGANISM(S): Homo sapiens  

SUBMITTER: Janos Demeter   Michael Whitfield  

PROVIDER: E-SMDB-2225 | ArrayExpress | 2005-10-19

REPOSITORIES: ArrayExpress

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Publications

Systemic and cell type-specific gene expression patterns in scleroderma skin.

Whitfield Michael L ML   Finlay Deborah R DR   Murray John Isaac JI   Troyanskaya Olga G OG   Chi Jen-Tsan JT   Pergamenschikov Alexander A   McCalmont Timothy H TH   Brown Patrick O PO   Botstein David D   Connolly M Kari MK  

Proceedings of the National Academy of Sciences of the United States of America 20031006 21


We used DNA microarrays representing >12,000 human genes to characterize gene expression patterns in skin biopsies from individuals with a diagnosis of systemic sclerosis with diffuse scleroderma. We found consistent differences in the patterns of gene expression between skin biopsies from individuals with scleroderma and those from normal, unaffected individuals. The biopsies from affected individuals showed nearly indistinguishable patterns of gene expression in clinically affected and clinica  ...[more]

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