Transcriptomics

Dataset Information

0

Transcription profiling of human breast tumor subtypes


ABSTRACT: Experiments that were used to make the "intrinsic" gene list from.

ORGANISM(S): Homo sapiens  

SUBMITTER: Charles Perou  Janos Demeter  Therese Sorlie       

PROVIDER: E-SMDB-2227 | ArrayExpress | 2005-10-13

REPOSITORIES: ArrayExpress

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Publications

Repeated observation of breast tumor subtypes in independent gene expression data sets.

Sorlie Therese T   Tibshirani Robert R   Parker Joel J   Hastie Trevor T   Marron J S JS   Nobel Andrew A   Deng Shibing S   Johnsen Hilde H   Pesich Robert R   Geisler Stephanie S   Demeter Janos J   Perou Charles M CM   Lønning Per E PE   Brown Patrick O PO   Børresen-Dale Anne-Lise AL   Botstein David D  

Proceedings of the National Academy of Sciences of the United States of America 20030626 14


Characteristic patterns of gene expression measured by DNA microarrays have been used to classify tumors into clinically relevant subgroups. In this study, we have refined the previously defined subtypes of breast tumors that could be distinguished by their distinct patterns of gene expression. A total of 115 malignant breast tumors were analyzed by hierarchical clustering based on patterns of expression of 534 "intrinsic" genes and shown to subdivide into one basal-like, one ERBB2-overexpressin  ...[more]

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