Transcriptomics

Dataset Information

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Transcription profiling of human clinical pediatric acute lymphoblastic leukemia (ALL) obtained from patients at diagnosis, human pretreatment, at least 70% blasts


ABSTRACT: Samples of pediatric acute lymphoblastic leukemia obtained from patients at diagnosis. All samples contain at least 77% blasts. Asparaginase LC50 values were determined for each of these samples. (LC50 was determined on a different aliquot of the same sample.)

ORGANISM(S): Homo sapiens  

SUBMITTER: Bernard Fine   Janos Demeter  

PROVIDER: E-SMDB-2820 | ArrayExpress | 2005-11-11

SECONDARY ACCESSION(S): E-SMDB-25

REPOSITORIES: ArrayExpress

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Publications

A genome-wide view of the in vitro response to l-asparaginase in acute lymphoblastic leukemia.

Fine Bernard M BM   Kaspers Gertjan J L GJ   Ho Minh M   Loonen Anne H AH   Boxer Linda M LM  

Cancer research 20050101 1


To investigate the effect of l-asparaginase on acute lymphoblastic leukemia (ALL), we used cDNA microarrays to obtain a genome-wide view of gene expression both at baseline and after in vitro exposure to l-asparaginase in cell lines and pediatric ALL samples. In 16 cell lines, a baseline gene expression pattern distinguished l-asparaginase sensitivity from resistance. However, for 28 pediatric ALL samples, no consistent baseline expression pattern was associated with sensitivity to l-asparaginas  ...[more]

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