Dataset Information


Transcription profiling of mouse host response to listeria infection, time series

ABSTRACT: This logical set encompases several 8hr timecourses (0,1,2,4,8 hrs) and their replicates. All correspond to treatments of bone marrow derived macrophages.

ORGANISM(S): Mus musculus  

SUBMITTER: Paul Fawcett   Janos Demeter  

PROVIDER: E-SMDB-2870 | ArrayExpress | 2005-11-03


altmetric image


A specific gene expression program triggered by Gram-positive bacteria in the cytosol.

McCaffrey Ramona L RL   Fawcett Paul P   O'Riordan Mary M   Lee Kyung-Dall KD   Havell Edward A EA   Brown Patrick O PO   Portnoy Daniel A DA  

Proceedings of the National Academy of Sciences of the United States of America 20040721 31

Innate and adaptive immunity depends critically on host recognition of pathogen-associated molecules. Toll-like receptors (TLRs) are key mediators of pathogen surveillance at the cell or phagocytic vacuole surface. However, mechanisms underlying recognition of pathogens in other cellular compartments remain unclear, and responses elicited by cytosolic challenge are poorly characterized. We therefore used mouse cDNA microarrays to investigate gene expression triggered by infection of bone marrow-  ...[more]

Similar Datasets

2006-01-07 | GSE3991 | GEO
2006-01-06 | E-GEOD-3991 | ArrayExpress
2007-04-23 | GSE7013 | GEO
| PRJEB8347 | ENA
| PRJEB87091 | ENA
2005-07-21 | E-SMDB-2231 | ArrayExpress
2008-06-15 | E-GEOD-7013 | ArrayExpress
2007-10-11 | E-TABM-250 | ArrayExpress
2005-01-01 | E-SMDB-7 | ArrayExpress
2014-11-01 | E-MTAB-3043 | ArrayExpress