Transcriptomics

Dataset Information

38

Transcription profiling of mouse host response to listeria infection, time series


ABSTRACT: This logical set encompases several 8hr timecourses (0,1,2,4,8 hrs) and their replicates. All correspond to treatments of bone marrow derived macrophages.

ORGANISM(S): Mus musculus  

SUBMITTER: Paul Fawcett  Janos Demeter     

PROVIDER: E-SMDB-2870 | ArrayExpress | 2014-05-02

REPOSITORIES: ArrayExpress

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Publications

A specific gene expression program triggered by Gram-positive bacteria in the cytosol.

McCaffrey Ramona L RL   Fawcett Paul P   O'Riordan Mary M   Lee Kyung-Dall KD   Havell Edward A EA   Brown Patrick O PO   Portnoy Daniel A DA  

Proceedings of the National Academy of Sciences of the United States of America 20040721 31


Innate and adaptive immunity depends critically on host recognition of pathogen-associated molecules. Toll-like receptors (TLRs) are key mediators of pathogen surveillance at the cell or phagocytic vacuole surface. However, mechanisms underlying recognition of pathogens in other cellular compartments remain unclear, and responses elicited by cytosolic challenge are poorly characterized. We therefore used mouse cDNA microarrays to investigate gene expression triggered by infection of bone marrow-  ...[more]

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