Transcriptomics

Dataset Information

31

Transcription profiling of childhood acute lymphoblastic leukemia ALL


ABSTRACT:

ORGANISM(S): Homo sapiens  

SUBMITTER: Janos Demeter  Matt Van De Rijn     

PROVIDER: E-SMDB-2907 | ArrayExpress| 2012-03-27

REPOSITORIES: ArrayExpress

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Publications


Most GISTs require oncogenic activation of the KIT or PDGFRA receptor tyrosine kinase proteins, and the genomic mechanisms of oncogene activation are heterogeneous. Notably, the kinase mutation type correlates with both tumor biology and imatinib response. For example, GISTs with KIT exon 11 mutations are typically gastric and have excellent imatinib response, whereas those with KIT exon 9 mutations generally arise in the small bowel and are less responsive to imatinib. To identify genes that mi  ...[more]

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