Dataset Information


Transcription profiling of human prostate cancer cells treated with resveratrol

ABSTRACT: Arrays for Expression levels of androgen-responsive genes in LNCaP cells exposed to dihydrotestosterone, R1881. Gene-expression changes in LNCaP treated with 1 nmol/L R1881 at 7, 9, 18, 24, 50, and 72 hours; 10 nmol/L dihydrotestosterone at 18 and 50 hours; 100 nmol/L dihydrotestosterone and 1 5mol/L dihydrotestosterone at 24 hours; and androgen deprivation at 46 and 70 hours.

ORGANISM(S): Homo sapiens  

SUBMITTER: Janos Demeter   Samuel DePrimo  

PROVIDER: E-SMDB-3259 | ArrayExpress | 2005-11-11


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Resveratrol-induced gene expression profiles in human prostate cancer cells.

Jones Sunita B SB   DePrimo Samuel E SE   Whitfield Michael L ML   Brooks James D JD  

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20050301 3

The transhydroxystilbene resveratrol is found at high levels in red wine and grapes, and red wine consumption may be inversely associated with prostate cancer risk. To gain insights into the possible mechanisms of action of resveratrol in human prostate cancer, we did DNA microarray analysis of the temporal transcriptional program induced by treatment of the human prostate cancer cell line LNCaP with resveratrol.Spotted DNA microarrays containing over 42,000 elements were used to obtain a global  ...[more]

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