Dataset Information


Transcription profiling of colon cancer cell lines to assess genetic instability

ABSTRACT: DNA microarray data accompanying Giacomini et al. "A signature of genetic instability in colon cancer". The first 18 and the following 13 arrays comprise the training and test sets, respectively. The last 3 arrays comprise the chromosome transfer lines.

ORGANISM(S): Homo sapiens  

SUBMITTER: Janos Demeter   Craig Giacomini  

PROVIDER: E-SMDB-3384 | ArrayExpress | 2005-10-18


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A gene expression signature of genetic instability in colon cancer.

Giacomini Craig P CP   Leung Suet Yi SY   Chen Xin X   Yuen Siu Tsan ST   Kim Young H YH   Bair Eric E   Pollack Jonathan R JR  

Cancer research 20051001 20

Genetic instability plays a central role in the development and progression of human cancer. Two major classes of genetic instability, microsatellite instability (MSI) and chromosome instability (microsatellite stable; MSS), are best understood in the context of colon cancer, where MSI tumors represent approximately 15% of cases, and compared with MSS tumors, more often arise in the proximal colon and display favorable clinical outcome. To further explore molecular differences, we profiled gene  ...[more]

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