Dataset Information


Transcription profiling of response to Hypoxia, cell type specificity and prognostic significance in human cancers

ABSTRACT: This 58 arrays are the basis of our hypoxia story published in PLoS Medicine. The cell type, oxygen tension and time points are indicated.

ORGANISM(S): Homo sapiens  

SUBMITTER: Janos Demeter   Jen-Tsan Ashley Chi  

PROVIDER: E-SMDB-3611 | ArrayExpress | 2006-06-06


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Inadequate oxygen (hypoxia) triggers a multifaceted cellular response that has important roles in normal physiology and in many human diseases. A transcription factor, hypoxia-inducible factor (HIF), plays a central role in the hypoxia response; its activity is regulated by the oxygen-dependent degradation of the HIF-1alpha protein. Despite the ubiquity and importance of hypoxia responses, little is known about the variation in the global transcriptional response to hypoxia among different cell  ...[more]