Transcriptomics

Dataset Information

2

Transcription profiling by array of human carcinomas of unknown primary


ABSTRACT: Carcinomas of unknown primary (CUP) are characterized by early metastatic dissemination in the absence of a detectable primary tumor. This disease accounts for about 3% of all malignant tumors. Most CUPs are poorly responsive to chemotherapy and have a rapid fatal evolution. The biological mechanisms supporting metastatic growth in various sites combined with regression or absence of growth in the primary site are still poorly understood. The aim of this project was to investigate characteristics of gene expression profile specific of CUPs with special attention to genes overexpressed or silenced in CUPs but not in classical secondary metastases. Three series of experiments were performed in 2006 and 2007. In all experiments, the mRNA used as a reference was obtained from diploid untransformed human fibroblasts (MRC5). The CUP samples were 2 xenografted CUP tumors (Capi1 and Capi3) and 4 CUP biopsies including a squamous carcinoma (Aud) and 3 adenocarcinomas (Gal, Pro, Gag). Samples representative of secondary metastases were xenografted tumors derived from metastases of nasopharyngeal carcinoma (C17), lung adenocarcinoma (IC14) and pancreatic adenocarcinoma (xenografted Capan 1 cell line) and one biopsy from a breast carcinoma (Vuc).

ORGANISM(S): Homo sapiens  

DISEASE(S): Secondary Metastases: Metastatic Nasopharyngeal Carcinoma,Reference,Secondary Metastases: Metastatic Pancreatic Adenocarcinoma,Secondary Metastases: Metastasis On Unknown Primary,Secondary Metastases: Adrenal Metastasis Of A Lung Adenocarcinoma,Secondary Metastases: Late Secondary Metastasis,Cup

SUBMITTER: Philippe Dessen  

PROVIDER: E-TABM-1058 | ArrayExpress | 2011-08-04

REPOSITORIES: ArrayExpress

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