Transcriptomics

Dataset Information

64

Transcription profiling by array of human ovary cell cultures stimulated with embryo-conditioned media


ABSTRACT: Stimulation of ovary cell cultures with embryo-conditioned media

ORGANISM(S): Homo sapiens  

SUBMITTER: Marian Groot Koerkamp  

PROVIDER: E-TABM-1064 | ArrayExpress | 2014-07-01

REPOSITORIES: ArrayExpress

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Publications


Human embryos frequently harbor large-scale complex chromosomal errors that impede normal development. Affected embryos may fail to implant although many first breach the endometrial epithelium and embed in the decidualizing stroma before being rejected via mechanisms that are poorly understood. Here we show that developmentally impaired human embryos elicit an endoplasmic stress response in human decidual cells. A stress response was also evident upon in vivo exposure of mouse uteri to culture  ...[more]

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