Dataset Information


Transcription profiling of Saccharomyces cerevisiae knock-outs of non-essential chromatin modifiers

ABSTRACT: Non-essential knockouts of chromatin modifiers have been investigated by expression profiling.

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: Patrick Kemmeren  

PROVIDER: E-TABM-1074 | ArrayExpress | 2011-08-05


Dataset's files

Action DRS
E-TABM-1074.README.txt Txt
E-TABM-1074.idf.txt Idf Processed Raw Raw
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Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator.

Gonzalez Deyarina D   Hamidi Nurul N   Del Sol Ricardo R   Benschop Joris J JJ   Nancy Thomas T   Li Chao C   Francis Lewis L   Tzouros Manuel M   Krijgsveld Jeroen J   Holstege Frank C P FC   Conlan R Steven RS  

Proceedings of the National Academy of Sciences of the United States of America 20140203 7

Mediator, an evolutionary conserved large multisubunit protein complex with a central role in regulating RNA polymerase II-transcribed genes, serves as a molecular switchboard at the interface between DNA binding transcription factors and the general transcription machinery. Mediator subunits include the Cdk8 module, which has both positive and negative effects on activator-dependent transcription through the activity of the cyclin-dependent kinase Cdk8, and the tail module, which is required fo  ...[more]

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