Transcriptomics

Dataset Information

3

Transcription profiling by array of M. musculus En1 -/- mouse midbrain E13.5 against pooled control +/+ littermates to investigate the specification of the mesodiencephalic dopaminergic system


ABSTRACT: Teresa Alves dos Santos: En1 -/- mouse midbrain E13.5 against pooled control +/+ littermates

ORGANISM(S): Mus musculus  

SUBMITTER: Marian Groot Koerkamp 

PROVIDER: E-TABM-1104 | ArrayExpress | 2013-08-07

REPOSITORIES: ArrayExpress

altmetric image

Publications


Mesodiencephalic dopaminergic (mdDA) neurons control locomotion and emotion and are affected in multiple psychiatric and neurodegenerative diseases, including Parkinson's disease (PD). The homeodomain transcription factor Pitx3 is pivotal in mdDA neuron development and loss of Pitx3 results in programming deficits in a rostrolateral subpopulation of mdDA neurons destined to form the substantia nigra pars compacta (SNc), reminiscent of the specific cell loss observed in PD. We show here that in a  ...[more]

Similar Datasets

2009-06-10 | E-TABM-711 | ArrayExpress
2014-12-11 | E-TABM-1105 | ArrayExpress
2014-07-01 | E-MTAB-1427 | ArrayExpress
2012-08-02 | E-TABM-1212 | ArrayExpress
2012-11-29 | E-TABM-1112 | ArrayExpress
2011-04-01 | E-TABM-981 | ArrayExpress
2012-08-03 | E-MTAB-953 | ArrayExpress
2015-12-31 | E-MTAB-2591 | ArrayExpress
2013-03-22 | E-TABM-1218 | ArrayExpress
2013-03-21 | E-TABM-1217 | ArrayExpress