Dataset Information


T-bet and GATA-3 act in combination through distal regulatory elements across the genome

ABSTRACT: Gene expression measurements in Thp, Th1 and Th2 cells polarised from naIve CD4+ T-cells isolated from wildtype and T-bet fl/fl x Cd4-Cre BALB/c mice or from WT and Gata-3 fl/fl x Tnfrsf4-Cre C57BL/6 mice.


ORGANISM(S): Mus musculus  

SUBMITTER: Richard Jenner  

PROVIDER: E-TABM-1187 | ArrayExpress | 2012-10-29


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Genome-wide regulatory analysis reveals that T-bet controls Th17 lineage differentiation through direct suppression of IRF4.

Gökmen M Refik MR   Dong Rong R   Kanhere Aditi A   Powell Nick N   Perucha Esperanza E   Jackson Ian I   Howard Jane K JK   Hernandez-Fuentes Maria M   Jenner Richard G RG   Lord Graham M GM  

Journal of immunology (Baltimore, Md. : 1950) 20131118 12

The complex relationship between Th1 and Th17 cells is incompletely understood. The transcription factor T-bet is best known as the master regulator of Th1 lineage commitment. However, attention is now focused on the repression of alternate T cell subsets mediated by T-bet, particularly the Th17 lineage. It has recently been suggested that pathogenic Th17 cells express T-bet and are dependent on IL-23. However, T-bet has previously been shown to be a negative regulator of Th17 cells. We have tak  ...[more]

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