Dataset Information


Transcription profiling by array of M. musculus ventral midbrains of E14.5 Pitx3-/- and Pitx3+/+ mouse embryos to investigate gene-regulatory pathways of Pitx3

ABSTRACT: RNA was isolated from dissected ventral midbrains of E14.5 Pitx3-/- and Pitx3+/+ mouse embryos. 3 Experimental samples each consisting of 3 Pitx3-/- ventral midbrains were hybridized to reference RNA derived from 10 Pitx3+/+ ventral midbrains

ORGANISM(S): Mus musculus  

SUBMITTER: M Groot Koerkamp  

PROVIDER: E-TABM-1209 | ArrayExpress | 2011-01-12


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Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons.

Jacobs Frank M J FM   Veenvliet Jesse V JV   Almirza Wadia H WH   Hoekstra Elisa J EJ   von Oerthel Lars L   van der Linden Annemarie J A AJ   Neijts Roel R   Koerkamp Marian Groot MG   van Leenen Dik D   Holstege Frank C P FC   Burbach J Peter H JP   Smidt Marten P MP  

Development (Cambridge, England) 20111201 23

Development of meso-diencephalic dopamine (mdDA) neurons requires the combined actions of the orphan nuclear receptor Nurr1 and the paired-like homeobox transcription factor Pitx3. Whereas all mdDA neurons require Nurr1 for expression of Th and survival, dependence on Pitx3 is displayed only by the mdDA subpopulation that will form the substantia nigra (SNc). Previously, we have demonstrated that Pitx3(-/-) embryos lack the expression of the retinoic acid (RA)-generating enzyme Ahd2, which is no  ...[more]

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