Transcriptomics

Dataset Information

121

Transcriptional profiling by array of stable HeLa cell line with doxycycline-inducible transcription factor E2F7 transgene


ABSTRACT: stable dox-inducible HeLa lines expressing E2F7

ORGANISM(S): Homo sapiens  

SUBMITTER: M Groot Koerkamp  

PROVIDER: E-TABM-1212 | ArrayExpress | 2012-08-02

REPOSITORIES: ArrayExpress

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Publications

E2F7 represses a network of oscillating cell cycle genes to control S-phase progression.

Westendorp Bart B   Mokry Michal M   Groot Koerkamp Marian J A MJ   Holstege Frank C P FC   Cuppen Edwin E   de Bruin Alain A  

Nucleic acids research 20111217 8


E2F transcription factors are known to be important for timely activation of G(1)/S and G(2)/M genes required for cell cycle progression, but transcriptional mechanisms for deactivation of cell cycle-regulated genes are unknown. Here, we show that E2F7 is highly expressed during mid to late S-phase, occupies promoters of G(1)/S-regulated genes and represses their transcription. ChIP-seq analysis revealed that E2F7 binds preferentially to genomic sites containing the TTCCCGCC motif, which closely  ...[more]

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