Dataset Information


Transcription profiling of bone marrow derived cells from mice stimulated with RANKL to generate osteoclasts in a time series

ABSTRACT: Bone marrow derived cells stimulated with RANKL (receptor activator of nuclear factor kappa B ligand, also known as Tumor necrosis factor ligand superfamily member 11) to generate osteoclasts.

ORGANISM(S): Mus musculus  

SUBMITTER: Rajeev Aurora  

PROVIDER: E-TABM-212 | ArrayExpress | 2007-06-06


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Systems level analysis of osteoclastogenesis reveals intrinsic and extrinsic regulatory interactions.

Kiesel Jennifer J   Miller Cheryl C   Abu-Amer Yousef Y   Aurora Rajeev R  

Developmental dynamics : an official publication of the American Association of Anatomists 20070801 8

Osteoclasts are bone-resorbing cells derived from the myeloid lineage that play a central role in bone remodeling and inflammatory bone erosion diseases. The receptor activator of NF-kappaB ligand (RANKL) produced by osteoblasts and activated immune cells initiates the development of osteoclasts in the bone marrow. Using time series gene expression data, the intrinsic processes and the extrinsic factors that control osteoclastogenesis were identified. The gene expression profiles display distinc  ...[more]

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