Dataset Information


Chromatin immunoprecipitation of centromeric proteins CenpC and CenpH from human cell lines containing a neocentromere in band 13q32

ABSTRACT: Chromatin Immunoprecipitation of Centromeric Proteins, CenpA, CenpC or CenpH from human cell lines containing a neocentromere in band 13q32

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ORGANISM(S): Homo sapiens  

SUBMITTER: Alicia Alonso  

PROVIDER: E-TABM-238 | ArrayExpress | 2008-03-22


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Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres.

Alonso Alicia A   Fritz Björn B   Hasson Dan D   Abrusan György G   Cheung Fanny F   Yoda Kinya K   Radlwimmer Bernhard B   Ladurner Andreas G AG   Warburton Peter E PE  

Genome biology 20070101 7

Mammalian centromere formation is dependent on chromatin that contains centromere protein (CENP)-A, which is the centromere-specific histone H3 variant. Human neocentromeres have acquired CENP-A chromatin epigenetically in ectopic chromosomal locations on low-copy complex DNA. Neocentromeres permit detailed investigation of centromeric chromatin organization that is not possible in the highly repetitive alpha satellite DNA present at endogenous centromeres.We have examined the distribution of CE  ...[more]

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