Transcriptomics

Dataset Information

46

Transcription profling of human neuroblastoma samples to construct, validate and evalute a gene expression based classification of outcome of treatment


ABSTRACT: This set of 320 profiles was utilized to construct, validate and evaluate a gene-expression based classifier of outcome of neuroblastoma patients

ORGANISM(S): Homo sapiens  

DISEASE(S): Neuroblastoma

SUBMITTER: Andre Oberthuer   Roland Eils  Frank Berthold  Yvonne Kahlert  Stefan Haas  Barbara Hero  Rainer Konig  Frank Westermann  Karen Ernestus  Rudiger Spitz  Matthias Fischer  Benedikt Brors  Manfred Schwab  Patrick Warnat 

PROVIDER: E-TABM-38 | ArrayExpress | 2009-02-17

REPOSITORIES: ArrayExpress

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Publications

GATA factors in human neuroblastoma: distinctive expression patterns in clinical subtypes.

Hoene V V   Fischer M M   Ivanova A A   Wallach T T   Berthold F F   Dame C C  

British journal of cancer 20090825 8


The aim of this study is to elucidate the expression patterns of GATA transcription factors in neuroblastoma and the developing sympathetic nervous system (SNS).GATA-2, -3 and -4 and their cofactor friend-of-GATA (FOG)-2 were investigated in primary neuroblastoma by immunohistochemistry, real-time RT-PCR (n=73) and microarray analysis (n=251). In addition, GATA-2, -3 and FOG-2 expression was determined by northern-blot hybridisation. In the developing murine SNS, Gata-4 and Fog-2 were examined b  ...[more]

Publication: 1/6

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