Transcriptomics

Dataset Information

4

MicroRNA profiling of patients with acute myeloid leukemia to identify microRNA signatures associated with cytogenetics and prognosis


ABSTRACT: MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia

ORGANISM(S): Homo sapiens  

DISEASE(S): Acute Myeloid Leukemia

SUBMITTER: Stefano Volinia  

PROVIDER: E-TABM-405 | ArrayExpress | 2008-01-10

REPOSITORIES: ArrayExpress

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Publications


MicroRNAs (miRNAs) are small RNAs of 19 to 25 nucleotides that are negative regulators of gene expression. To determine whether miRNAs are associated with cytogenetic abnormalities and clinical features in acute myeloid leukemia (AML), we evaluated the miRNA expression of CD34(+) cells and 122 untreated adult AML cases using a microarray platform. After background subtraction and normalization using a set of housekeeping genes, data were analyzed using Significance Analysis of Microarrays. An in  ...[more]

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