Transcriptomics

Dataset Information

9

MicroRNA profiling of human chronic lymphocytic leukemia samples to identify whether microRNA profiles are prognostic indicators


ABSTRACT: MicroRNA expression profiles can distinguish normal B cells from malignant B cells in chronic lymphocytic leukemia (CLL). We investigated whether microRNA profiles are associated with known prognostic factors in CLL. We evaluated the microRNA expression profiles of 94 samples of CLL cells for which ZAP-70 expression, mutations in the rearranged IgVH gene, and the time from diagnosis to initial treatment were known. We also investigated the presence of abnormalities in the genomic sequence of 42 microRNA genes.

INSTRUMENT(S): ScanArray 4000XL [PerkinElmer]

ORGANISM(S): Homo sapiens  

DISEASE(S): Chronic Lymphocytic Leukemia,Normal

SUBMITTER: Claudia Roldo   Carlo M. Croce  Ramiro Garzon  Masayoshi Shimizu  George Calin  Muller Fabbri  Rodolfo Iuliano  Manuela Ferracin  Amelia Cimmino  Massimo Negrini  Hansjuerg Alder  George A. Calin  Gianpiero Di Leva  Sylwia Wojcik  Rosa Visone  Marilena V. Iorio  Flavia Pichiorri  Thomas J. Kipps  Cinzia Sevignani  Stefano Volinia  Chang-gong Liu  Laura Rassenti  Tiziana Palumbo  Nuretin I. Sever 

PROVIDER: E-TABM-41 | ArrayExpress | 2005-10-27

REPOSITORIES: ArrayExpress

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Publications


BACKGROUND: MicroRNA expression profiles can be used to distinguish normal B cells from malignant B cells in patients with chronic lymphocytic leukemia (CLL). We investigated whether microRNA profiles are associated with known prognostic factors in CLL. METHODS: We evaluated the microRNA expression profiles of 94 samples of CLL cells for which the level of expression of 70-kD zeta-associated protein (ZAP-70), the mutational status of the rearranged immunoglobulin heavy-chain variable-region (IgV  ...[more]

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