Transcriptomics

Dataset Information

47

Transcription profiling of human chronic lymphocytic leukemia miRNA expression validation


ABSTRACT: MicroRNA expression profiles can distinguish normal B cells from malignant B cells in chronic lymphocytic leukemia (CLL). We investigated whether microRNA profiles are associated with known prognostic factors in CLL. We evaluated the microRNa expression profiles of 94 samples of CLL cells for which ZAP-70 expression; mutations in the rearranged IgVH gene; and the time from diagnosis to initial treatment were known. We also investigated the presence of abnormalities in the genomic sequence of 42 microRNA genes.

INSTRUMENT(S): Axon GenePix 4000B scanner

ORGANISM(S): Homo sapiens  

DISEASE(S): Chronic Lymphocytic Leukemia

SUBMITTER: Claudia Roldo  Carlo M. Croce  Ramiro Garzon  George Calin  Masayoshi Shimizu  Muller Fabbri  Rodolfo Iuliano  Manuela Ferracin  Massimo Negrini  Amelia Cimmino  Hansjuerg Alder  Gianpiero Di Leva  Rosa Visone  Sylwia Wojcik  Marilena V. Iorio  Cinzia Sevignani  Thomas J. Kipps  Flavia Pichiorri  George Adrian Calin  Stefano Volinia  Chang-gong Liu  Laura Rassenti  Nuretin Ilfer Sever  Tiziana Palumbo 

PROVIDER: E-TABM-42 | ArrayExpress | 2005-10-27

REPOSITORIES: ArrayExpress

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Publications


BACKGROUND: MicroRNA expression profiles can be used to distinguish normal B cells from malignant B cells in patients with chronic lymphocytic leukemia (CLL). We investigated whether microRNA profiles are associated with known prognostic factors in CLL. METHODS: We evaluated the microRNA expression profiles of 94 samples of CLL cells for which the level of expression of 70-kD zeta-associated protein (ZAP-70), the mutational status of the rearranged immunoglobulin heavy-chain variable-region (IgV  ...[more]

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