Transcriptomics

Dataset Information

6

MicroRNA profiling of human chorioamniotic membranes from women at term in labor, women at term not in labor and women who deliverd preterm


ABSTRACT: Comparing miRNAs expression levels in chorioamniotic membranes from women at term in labor (TL), women at term not in labor (TNL) and women who deliverd preterm (PTLC). The goal was to see if miRNA levels are indicators of preterm delivery or spontaneous labor at term. A two-channel technology was used in this experiment in which a pooled reference RNA was used for competitive hybridization. The pooled reference was generated at Exiqon in Denmark from a mixture of several human tissues (placenta, thyroid, brain, adipose, spleen, liver, colon, skeletal muscle, ovary, kidney, heart, cervix, testes, esophagus, small intestine, prostate, trachea, thymus, bladder, lung).

ORGANISM(S): Homo sapiens  

SUBMITTER: Adi Tarca  

PROVIDER: E-TABM-469 | ArrayExpress | 2008-10-01

REPOSITORIES: ArrayExpress

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Publications

Expression patterns of microRNAs in the chorioamniotic membranes: a role for microRNAs in human pregnancy and parturition.

Montenegro D D   Romero R R   Kim S S SS   Tarca A L AL   Draghici S S   Kusanovic J P JP   Kim J S JS   Lee D C DC   Erez O O   Gotsch F F   Hassan S S SS   Kim C J CJ  

The Journal of pathology 20090101 1


MicroRNAs (miRNAs) are involved in the post-transcriptional regulation of gene expression during development. This study was performed to determine gestational age-dependent changes in miRNA expression in the chorioamniotic membranes and to assess the significance of miRNAs in human pregnancy and parturition. The expression profile of 455 miRNAs was compared between patients at term without labour (TNL: n = 10), in labour (TL: n = 10), and preterm labour (PTL: n = 10) using microarrays. A total  ...[more]

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