Transcriptomics

Dataset Information

6

MicroRNA profiling of human normal lung and lung cancer samples to investigate the role of miRNA involvement in lung carcinogenesis


ABSTRACT: MicroRNA (miRNA) expression profiles for lung cancers were examined to investigate the miRNA involvement in lung carcinogenesis. miRNA microarray analysis identified statistical unique profiles, which could discriminate lung cancers from noncancerous lung tissues.

INSTRUMENT(S): ScanArray 4000XL [PerkinElmer]

ORGANISM(S): Homo sapiens  

DISEASE(S): Lung Cancer,Normal

SUBMITTER: Claudia Roldo   Carlo M. Croce  Giovanni Lanza  Fabio Petrocca  Aldo Scarpa  Manuela Ferracin  Massimo Negrini  Amelia Cimmino  Nozumu Yanaihara  George A. Calin  Rosa Visone  Stefan Ambs  Chang-Gong Liu  Marilena Iorio  Curtis C. Harris  Stefano Volinia  Andrea Vecchione 

PROVIDER: E-TABM-47 | ArrayExpress | 2005-12-31

REPOSITORIES: ArrayExpress

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Publications


Small noncoding microRNAs (miRNAs) can contribute to cancer development and progression and are differentially expressed in normal tissues and cancers. From a large-scale miRnome analysis on 540 samples including lung, breast, stomach, prostate, colon, and pancreatic tumors, we identified a solid cancer miRNA signature composed by a large portion of overexpressed miRNAs. Among these miRNAs are some with well characterized cancer association, such as miR-17-5p, miR-20a, miR-21, miR-92, miR-106a,  ...[more]

Publication: 1/2

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