Transcriptomics

Dataset Information

55

MicroRNA profiling of human pancreatic endocrine tumors


ABSTRACT: MicroRNA (miRNA) expression profiles for pancreatic endocrine tumors were examined to investigate the miRNA involvement in pancreatic carcinogenesis. miRNA microarray analysis identified statistical unique profiles, which could discriminate pancreatic cancers from noncancerous pancreas tissues.

INSTRUMENT(S): Scanning hardware

ORGANISM(S): Homo sapiens  

DISEASE(S): Insulinoma,Acinar Cell Carcinoma,Nonfunctioning Endocrine Tumors,Normal

SUBMITTER: Stefano Volinia  

PROVIDER: E-TABM-48 | ArrayExpress | 2007-05-11

REPOSITORIES: ArrayExpress

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Publications


Small noncoding microRNAs (miRNAs) can contribute to cancer development and progression and are differentially expressed in normal tissues and cancers. From a large-scale miRnome analysis on 540 samples including lung, breast, stomach, prostate, colon, and pancreatic tumors, we identified a solid cancer miRNA signature composed by a large portion of overexpressed miRNAs. Among these miRNAs are some with well characterized cancer association, such as miR-17-5p, miR-20a, miR-21, miR-92, miR-106a,  ...[more]

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