Transcriptomics

Dataset Information

50

MicroRNA profiling of human normal prostate and prostate cancer samples to investigate the role of miRNA involvement in prostate carcinogenesis


ABSTRACT: MicroRNA (miRNA) expression profiles for prostate cancers were examined to investigate the miRNA involvement in prostate carcinogenesis. miRNA microarray analysis identified statistical unique profiles, which could discriminate prostate cancers from noncancerous prostate tissues.

INSTRUMENT(S): Scanning hardware

ORGANISM(S): Homo sapiens  

DISEASE(S): Prostate Adenocarcinoma,Normal

SUBMITTER: Claudia Roldo   Carlo M. Croce  Giovanni Lanza  Fabio Petrocca  Aldo Scarpa  Manuela Ferracin  Massimo Negrini  Amelia Cimmino  Nozumu Yanaihara  George A. Calin  Rosa Visone  Stefan Ambs  Chang-Gong Liu  Marilena Iorio  Curtis C. Harris  Stefano Volinia  Andrea Vecchione 

PROVIDER: E-TABM-49 | ArrayExpress | 2005-12-31

REPOSITORIES: ArrayExpress

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Publications


Small noncoding microRNAs (miRNAs) can contribute to cancer development and progression and are differentially expressed in normal tissues and cancers. From a large-scale miRnome analysis on 540 samples including lung, breast, stomach, prostate, colon, and pancreatic tumors, we identified a solid cancer miRNA signature composed by a large portion of overexpressed miRNAs. Among these miRNAs are some with well characterized cancer association, such as miR-17-5p, miR-20a, miR-21, miR-92, miR-106a,  ...[more]

Publication: 1/2

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