Dataset Information


Transcription profiling of mouse muscle tissue after in-vivo intramuscularly administration of MF59, CpG, MF59+CpG, alum and PBS

ABSTRACT: Analysis of whole mouse muscle gene expression signature induced by in-vivo intramuscularly administration of MF59, CpG, MF59+CpG, alum and PBS. MF59 and alum are licensed human vaccine adjuvants; CpG is a TLR-agonist adjuvant.

ORGANISM(S): Mus musculus  

TISSUE(S): Muscle

SUBMITTER: Mosca Flaviana  

PROVIDER: E-TABM-506 | ArrayExpress | 2009-07-03


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Molecular and cellular signatures of human vaccine adjuvants.

Mosca F F   Tritto E E   Muzzi A A   Monaci E E   Bagnoli F F   Iavarone C C   O'Hagan D D   Rappuoli R R   De Gregorio E E  

Proceedings of the National Academy of Sciences of the United States of America 20080723 30

Oil-in-water emulsions are potent human adjuvants used for effective pandemic influenza vaccines; however, their mechanism of action is still unknown. By combining microarray and immunofluorescence analysis, we monitored the effects of the adjuvants MF59 oil-in-water emulsion, CpG, and alum in the mouse muscle. MF59 induced a time-dependent change in the expression of 891 genes, whereas CpG and alum regulated 387 and 312 genes, respectively. All adjuvants modulated a common set of 168 genes and  ...[more]

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