Dataset Information


MicroRNA profiling of human multiple myeloma cells and monoclonal gammopathy of undetermined significance (MGUS) cells

ABSTRACT: MicroRNA expression profiles for human Multilple Myeloma and MGUS (monoclonal gammopathy of undetermined significance) were examined to investigate the miRNA involvement in the development of this neoplasia.

INSTRUMENT(S): Scanning hardware

ORGANISM(S): Homo sapiens  

DISEASE(S): Normal,Monoclonal Gammopathy Of Undetermined Significance,Multiple Myeloma

SUBMITTER: Cristian Taccioli  

PROVIDER: E-TABM-508 | ArrayExpress | 2008-09-03


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Progress in understanding the biology of multiple myeloma (MM), a plasma cell malignancy, has been slow. The discovery of microRNAs (miRNAs), a class of small noncoding RNAs targeting multiple mRNAs, has revealed a new level of gene expression regulation. To determine whether miRNAs play a role in the malignant transformation of plasma cells (PCs), we have used both miRNA microarrays and quantitative real time PCR to profile miRNA expression in MM-derived cell lines (n = 49) and CD138+ bone marr  ...[more]

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