Transcriptomics

Dataset Information

4

Transcription profiling of human lung large cell carncinoma cells grown under hypoxic conditions and treated with STAT3 siRNA


ABSTRACT: Hypoxia-mediated inhibition of specific tumour cell lysis

ORGANISM(S): Homo sapiens  

DISEASE(S): Large Cell Carcinoma

SUBMITTER: Philippe DESSEN  

PROVIDER: E-TABM-611 | ArrayExpress | 2009-03-12

REPOSITORIES: ArrayExpress

altmetric image

Publications

The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis.

Noman Muhammad Zaeem MZ   Buart Stéphanie S   Van Pelt Jos J   Richon Catherine C   Hasmim Meriem M   Leleu Nathalie N   Suchorska Wictoria Maria WM   Jalil Abdelali A   Lecluse Yann Y   El Hage Faten F   Giuliani Massimo M   Pichon Christophe C   Azzarone Bruno B   Mazure Nathalie N   Romero Pedro P   Mami-Chouaib Fathia F   Chouaib Salem S  

Journal of immunology (Baltimore, Md. : 1950) 20090301 6


Hypoxia is an essential component of tumor microenvironment. In this study, we investigated the influence of hypoxia (1% PO(2)) on CTL-mediated tumor cell lysis. We demonstrate that exposure of target tumor cells to hypoxia has an inhibitory effect on the CTL clone (Heu171)-induced autologous target cell lysis. Such inhibition correlates with hypoxia-inducible factor-1alpha (HIF-1alpha) induction but is not associated with an alteration of CTL reactivity as revealed by granzyme B polarization or  ...[more]

Similar Datasets

2007-03-02 | E-TABM-208 | ArrayExpress
2008-01-26 | E-TABM-211 | ArrayExpress
2010-03-18 | E-TABM-899 | ArrayExpress
2012-11-01 | E-MTAB-1157 | ArrayExpress
2010-09-11 | E-TABM-792 | ArrayExpress
2006-01-23 | E-TABM-71 | ArrayExpress
2006-09-11 | E-TABM-44 | ArrayExpress
2009-03-19 | E-TABM-549 | ArrayExpress
2018-11-07 | E-MTAB-4869 | ArrayExpress
2009-09-14 | E-TABM-640 | ArrayExpress