Dataset Information


Transcription profiling of human lung large cell carncinoma cells grown under hypoxic conditions and treated with STAT3 siRNA

ABSTRACT: Hypoxia-mediated inhibition of specific tumour cell lysis

ORGANISM(S): Homo sapiens  

DISEASE(S): Large Cell Carcinoma


PROVIDER: E-TABM-611 | ArrayExpress | 2009-03-12


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The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis.

Noman Muhammad Zaeem MZ   Buart Stéphanie S   Van Pelt Jos J   Richon Catherine C   Hasmim Meriem M   Leleu Nathalie N   Suchorska Wictoria Maria WM   Jalil Abdelali A   Lecluse Yann Y   El Hage Faten F   Giuliani Massimo M   Pichon Christophe C   Azzarone Bruno B   Mazure Nathalie N   Romero Pedro P   Mami-Chouaib Fathia F   Chouaib Salem S  

Journal of immunology (Baltimore, Md. : 1950) 20090301 6

Hypoxia is an essential component of tumor microenvironment. In this study, we investigated the influence of hypoxia (1% PO(2)) on CTL-mediated tumor cell lysis. We demonstrate that exposure of target tumor cells to hypoxia has an inhibitory effect on the CTL clone (Heu171)-induced autologous target cell lysis. Such inhibition correlates with hypoxia-inducible factor-1alpha (HIF-1alpha) induction but is not associated with an alteration of CTL reactivity as revealed by granzyme B polarization or  ...[more]

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