Transcriptomics

Dataset Information

7

Kinase activity profiling shows osteoblast-induced EGFR/ERBB2 signaling in human androgen-sensitive prostate carcinoma cells


ABSTRACT: Osteoblast-induced EGFR/ERBB2 signaling in androgen-sensitive prostate carcinoma cells characterized by multiplex kinase activity profiling

ORGANISM(S): Homo sapiens  

DISEASE(S): Osteosarcoma,Prostate Carcinoma

SUBMITTER: Anne Hansen Ree  

PROVIDER: E-TABM-626 | ArrayExpress | 2009-04-02

REPOSITORIES: ArrayExpress

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Publications

Osteoblast-induced EGFR/ERBB2 signaling in androgen-sensitive prostate carcinoma cells characterized by multiplex kinase activity profiling.

Bratland Ase A   Boender Piet J PJ   Høifødt Hanne K HK   Østensen Ingrid H G IH   Ruijtenbeek Rob R   Wang Meng-Yu MY   Berg Jens P JP   Lilleby Wolfgang W   Fodstad Øystein Ø   Ree Anne Hansen AH  

Clinical & experimental metastasis 20090318 5


Bone metastases in prostate cancer are predominantly osteoblastic. To study regulatory mechanisms underlying the establishment of prostate cancer within an osteoblastic microenvironment, human androgen-sensitive prostate carcinoma cells (LNCaP) were treated with culture medium conditioned by human osteoblast-derived sarcoma cells (OHS), and activated signalling pathways in the carcinoma cells were analyzed using microarrays with tyrosine kinase substrates. Network interaction analysis of substra  ...[more]

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