Transcriptomics

Dataset Information

62

Transcription profiling of fission yeast wild type and yox1 mutant strains


ABSTRACT: Transcription profiling of fission yeast /yox1/ deletion and genome wide location analysis of Yox1p and Cdc10p transcription factors reveal a negative feedback interaction: /yox1 /is transcriptionally activated by MBF, and Yox1p in turn transcriptionally represses the MBF target genes (including /yox1 /itself).

INSTRUMENT(S): 418 [Affymetrix], Axon GenePix 4000B scanning hardware

ORGANISM(S): Schizosaccharomyces pombe  

SUBMITTER: Gabriella Rustici  

PROVIDER: E-TABM-646 | ArrayExpress | 2009-08-20

REPOSITORIES: ArrayExpress

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Publications

The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.

Aligianni Sofia S   Lackner Daniel H DH   Klier Steffi S   Rustici Gabriella G   Wilhelm Brian T BT   Marguerat Samuel S   Codlin Sandra S   Brazma Alvis A   de Bruin Robertus A M RA   Bähler Jürg J  

PLoS genetics 20090828 8


The regulation of the G1- to S-phase transition is critical for cell-cycle progression. This transition is driven by a transient transcriptional wave regulated by transcription factor complexes termed MBF/SBF in yeast and E2F-DP in mammals. Here we apply genomic, genetic, and biochemical approaches to show that the Yox1p homeodomain protein of fission yeast plays a critical role in confining MBF-dependent transcription to the G1/S transition of the cell cycle. The yox1 gene is an MBF target, and  ...[more]

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