Transcriptomics

Dataset Information

6

Chromatin immunoprecipitation of Drosophila to identify Twist protein binding during embryonic development


ABSTRACT: Genomewide mapping of D. melanogaster Twist protein binding during embryonic development. Three consecutive timepoints (2-4, 4-6, 6-8 hrs after egg-laying) were assayed in two independent repeats each. Two different antibodies were used to precipitate the Twist protein. Additionally the respective preimmune-serum was used as a control for every precipitation. The enriched DNA was hybridized to high density Affymetrix GeneChip Drosophila Tiling 1.0R array.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Drosophila Melanogaster

SUBMITTER: Charles Girardot  

PROVIDER: E-TABM-651 | ArrayExpress | 2009-11-09

REPOSITORIES: ArrayExpress

Dataset's files

Source:
Action DRS
E-TABM-651.README.txt Txt
E-TABM-651.eSet.r Other
E-TABM-651.idf.txt Idf
E-TABM-651.idf.txt_original Idf
E-TABM-651.raw.1.zip Raw
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Publications


The transcription factors of the Snail family are key regulators of epithelial-mesenchymal transitions, cell morphogenesis, and tumor metastasis. Since its discovery in Drosophila ∼25 years ago, Snail has been extensively studied for its role as a transcriptional repressor. Here we demonstrate that Drosophila Snail can positively modulate transcriptional activation. By combining information on in vivo occupancy with expression profiling of hand-selected, staged snail mutant embryos, we identifie  ...[more]

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