Transcriptomics

Dataset Information

62

MicroRNA profiling of human primary hepatocytes treated with CDCA, GW4064 or FGF19


ABSTRACT: We studied the effect of bile acid CDCA, FXR agonsit GW4064 and FGF19 on the expression levels of microRNA in cultured human primary hepatocytes

ORGANISM(S): Homo sapiens  

SUBMITTER: Tiangang Li John YL Chiang  

PROVIDER: E-TABM-691 | ArrayExpress | 2010-04-20

REPOSITORIES: ArrayExpress

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Publications

A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes.

Song Kwang-Hoon KH   Li Tiangang T   Owsley Erika E   Chiang John Y L JY  

Journal of lipid research 20100329 8


Cholesterol 7alpha-hydroxylase (CYP7A1) plays a critical role in regulation of bile acid synthesis in the liver. CYP7A1 mRNAs have very short half-lives, and bile acids destabilize CYP7A1 mRNA via the 3'-untranslated region (3'-UTR). However, the underlying mechanism of translational regulation of CYP7A1 mRNA remains unknown. Screening of a human micro RNA (miRNA) microarray has identified five differentially expressed miRNAs in human primary hepatocytes treated with chenodeoxycholic acid, GW406  ...[more]

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