Dataset Information


Comparative genomic hybridization and transcription profiling of human and mouse T cells in differentiation

ABSTRACT: ChIP-Chip for T-bet and GATA-3 in human Th1 and Th2 cells, gene expression profiling of human Th1 and Th2 cells and of T-cells from T-bet-deficient mice,

SUBMITTER: Richard Jenner  

PROVIDER: E-TABM-759 | ArrayExpress | 2009-10-26


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The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes.

Jenner Richard G RG   Townsend Michael J MJ   Jackson Ian I   Sun Kaiming K   Bouwman Russell D RD   Young Richard A RA   Glimcher Laurie H LH   Lord Graham M GM  

Proceedings of the National Academy of Sciences of the United States of America 20091005 42

Upon detection of antigen, CD4(+) T helper (Th) cells can differentiate into a number of effector types that tailor the immune response to different pathogens. Alternative Th1 and Th2 cell fates are specified by the transcription factors T-bet and GATA-3, respectively. Only a handful of target genes are known for these two factors and because of this, the mechanism through which T-bet and GATA-3 induce differentiation toward alternative cell fates is not fully understood. Here, we provide a geno  ...[more]

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