Genomics

Dataset Information

485

ChIP-Seq of human MCF7 and HEPG2 cells using antibodies against CTCF, STAG1, RAD2, ERa and CEBPa


ABSTRACT: ChIP-Seq study in human MCF7 and HEPG2 cells using antibodies against CTCF (Millipore, 07-729), STAG1 (abcam, ab4457), RAD21 (abcam, ab992), ERa (santa cruz, sc-543), CEBPa (santa cruz, sc-9314)

INSTRUMENT(S): Illumina Genome Analyzer

ORGANISM(S): Homo sapiens  

SUBMITTER: Petra Catalina Schwalie  

PROVIDER: E-TABM-828 | ArrayExpress | 2010-05-13

SECONDARY ACCESSION(S): ERP000209

REPOSITORIES: ArrayExpress, ENA

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Publications


Cumulative exposure to estrogen (E) and progesterone (P) over the menstrual cycle significantly influences the risk of developing breast cancer. Despite the dogma that PR in the breast merely serves as a marker of an active estrogen receptor (ER), and as an inhibitor of the proliferative actions of E, it is now clear that in the breast P increases proliferation independently of E action. We show here that the progesterone receptor (PR) and ER are expressed in different epithelial populations, an  ...[more]

Publication: 1/2

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