Dataset Information


Transcription profiling by array of human THP-1 cells overexpressing or silenced for GAM after treatment with lipopolysaccharide

ABSTRACT: 24 hours following transfection with either a control mix, a construct overexpressing GAM or siRNAs directed against GAM (siGAM), THP-1 cells were challenged with LPS 100 ng/ml. RNAs were analyzed after 6 hours of LPS challenge

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo Sapiens

DISEASE(S): Acute Monocytic Leukemia

SUBMITTER: Cristian Taccioli  

PROVIDER: E-TABM-868 | ArrayExpress | 2010-06-09


Dataset's files

Action DRS
E-TABM-868.idf.txt Idf Raw
E-TABM-868.sdrf.txt Txt
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GAM/ZFp/ZNF512B is central to a gene sensor circuitry involving cell-cycle regulators, TGF{beta} effectors, Drosha and microRNAs with opposite oncogenic potentials.

Tili Esmerina E   Michaille Jean-Jacques JJ   Liu Chang-Gong CG   Alder Hansjuerg H   Taccioli Cristian C   Volinia Stefano S   Calin George A GA   Croce Carlo M CM  

Nucleic acids research 20100717 21

MicroRNAs (miRNAs) are small regulatory RNAs targeting multiple effectors of cell homeostasis and development, whose malfunctions are associated with major pathologies such as cancer. Herein we show that GAM/ZFp/ZNF512B works within an intricate gene regulatory network involving cell-cycle regulators, TGFβ effectors and oncogenic miRNAs of the miR-17-92 cluster. Thus, GAM impairs the transcriptional activation of the miR-17-92 promoter by c-Myc, downregulates miR-17-92 miRNAs differentially, and  ...[more]

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