Transcriptomics

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Transcription profiling of human ependymomas at diagnosis and at relapse to investigate key molecular events involved in tumor progression


ABSTRACT: Goal of the experiment Recurrence is a frequent phenomenon in intracranial childhood ependymomas. To understand this process, we investigated whether the gene expression profiling of matched ependymomas at diagnosis and at relapse could reveal key molecular events involved in tumor progression. To gain new insight in this process and identify pathways associated with recurrence, we compared the gene expression profiles of local recurrences with the corresponding initial tumors. Brief description We analyzed 17 tumor samples at diagnosis and a total of 27 paired recurrences. Recurrences analyzed occurred after surgery only in 12 cases, surgery plus chemotherapy only in 9 cases and any treatment plus radiotherapy in 6 cases. We compared the level of gene expression for each tumor at recurrence relative to its expression at diagnosis using Agilent 44K dual color gene expression microarrays.

ORGANISM(S): Homo sapiens  

DISEASE(S): Ependymoma

SUBMITTER: Philippe DESSEN  

PROVIDER: E-TABM-873 | ArrayExpress | 2010-12-31

REPOSITORIES: ArrayExpress

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Publications

Portrait of ependymoma recurrence in children: biomarkers of tumor progression identified by dual-color microarray-based gene expression analysis.

Peyre Matthieu M   Commo Frédéric F   Dantas-Barbosa Carmela C   Andreiuolo Felipe F   Puget Stéphanie S   Lacroix Ludovic L   Drusch Françoise F   Scott Véronique V   Varlet Pascale P   Mauguen Audrey A   Dessen Philippe P   Lazar Vladimir V   Vassal Gilles G   Grill Jacques J  

PloS one 20100924 9


BACKGROUND: Children with ependymoma may experience a relapse in up to 50% of cases depending on the extent of resection. Key biological events associated with recurrence are unknown. METHODOLOGY/PRINCIPAL FINDINGS: To discover the biology behind the recurrence of ependymomas, we performed CGHarray and a dual-color gene expression microarray analysis of 17 tumors at diagnosis co-hybridized with the corresponding 27 first or subsequent relapses from the same patient. As treatment and location had  ...[more]

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