Dataset Information


Transcription profiling of mouse white adipose tissue from ApoE3L strain exposed to high-fat diet.

ABSTRACT: Our aim was to investigate gene expression changes over time in white adipose tissue of ApOE3*Leiden mice on a high-fat diet

ORGANISM(S): Mus musculus  

TISSUE(S): Epididymal Adipose Tissue, Mesenteric Adipose Tissue, Subcutaneous Adipose Tissue

SUBMITTER: Robet Caesar 

PROVIDER: E-TABM-884 | ArrayExpress | 2011-01-11


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A combined transcriptomics and lipidomics analysis of subcutaneous, epididymal and mesenteric adipose tissue reveals marked functional differences.

Caesar Robert R   Manieri Monia M   Kelder Thomas T   Boekschoten Mark M   Evelo Chris C   Müller Michael M   Kooistra Teake T   Cinti Saverio S   Kleemann Robert R   Drevon Christian A CA  

PloS one 20100712 7

Depot-dependent differences in adipose tissue physiology may reflect specialized functions and local interactions between adipocytes and surrounding tissues. We combined time-resolved microarray analyses of mesenteric- (MWAT), subcutaneous- (SWAT) and epididymal adipose tissue (EWAT) during high-fat feeding of male transgenic ApoE3Leiden mice with histology, targeted lipidomics and biochemical analyses of metabolic pathways to identify differentially regulated processes and site-specific functio  ...[more]

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