Transcriptomics

Dataset Information

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Transcription profiling of human paediatric glioblastoma cells treated with insulin-like growth factor 1 receptor inhibitors


ABSTRACT: We have previously determined the insulin-like growth factor 1 receptor (IGF1R) to be amplified and overexpressed in paediatric glioblastoma. In order to probe the efficacy and mechanisms of action of various inhibitors of the receptor, we have carried out expression profiling of paediatric glioblastoma cells treated with 5x IC50 of the compounds PPP and NVP-AEW541 over a 24 hour time-course.

ORGANISM(S): Homo sapiens  

DISEASE(S): Glioblastoma

SUBMITTER: Anita Grigoriadis   

PROVIDER: E-TABM-889 | ArrayExpress | 2014-05-02

REPOSITORIES: ArrayExpress

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Publications


Pediatric glioblastoma (pGBM), although rare, is one of the leading causes of cancer-related deaths in children, with tumors essentially refractory to existing treatments. We have identified IGF1R to be a potential therapeutic target in pGBM due to gene amplification and high levels of IGF2 expression in some tumor samples, as well as constitutive receptor activation in pGBM cell lines. To evaluate the therapeutic potential of strategies targeting the receptor, we have carried out in vitro and i  ...[more]

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