Dataset Information


Transcription profiling by array of human lymphocytes from prostate carcinoma patients after X-radiation treatment

ABSTRACT: For a case-control study, we selected 54 prostate carcinoma patients with no evidence of disease 2 years after curative


INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Binie Klein   Rebecca E.E. Esveldt-van Lange  Harry Vrieling  J Peter Svensson  Jaap Haveman  Ingela Turesson  Lukas J.A. Stalpers  Nicolaas A.P. Franken  Micheline Giphart-Gassler 

PROVIDER: E-TABM-90 | ArrayExpress | 2007-12-01


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Analysis of gene expression using gene sets discriminates cancer patients with and without late radiation toxicity.

Svensson J Peter JP   Stalpers Lukas J A LJ   Esveldt-van Lange Rebecca E E RE   Franken Nicolaas A P NA   Haveman Jaap J   Klein Binie B   Turesson Ingela I   Vrieling Harry H   Giphart-Gassler Micheline M  

PLoS medicine 20061001 10

BACKGROUND: Radiation is an effective anti-cancer therapy but leads to severe late radiation toxicity in 5%-10% of patients. Assuming that genetic susceptibility impacts this risk, we hypothesized that the cellular response of normal tissue to X-rays could discriminate patients with and without late radiation toxicity. METHODS AND FINDINGS: Prostate carcinoma patients without evidence of cancer 2 y after curative radiotherapy were recruited in the study. Blood samples of 21 patients with severe  ...[more]

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