Transcriptomics

Dataset Information

36

Kinase activity profiling of human locally advanced rectal cancer samples


ABSTRACT: Locally advanced rectal cancer characterized by multiplex kinase activity profiling

ORGANISM(S): Homo sapiens  

DISEASE(S): Locally Advanced Rectal Cancer

SUBMITTER: Anne Hansen Ree   

PROVIDER: E-TABM-913 | ArrayExpress| 2014-05-02

REPOSITORIES: ArrayExpress

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Publications

Prediction of response to preoperative chemoradiotherapy in rectal cancer by multiplex kinase activity profiling.

Folkvord Sigurd S   Flatmark Kjersti K   Dueland Svein S   de Wijn Rik R   Grøholt Krystyna Kotanska KK   Hole Knut H KH   Nesland Jahn M JM   Ruijtenbeek Rob R   Boender Piet J PJ   Johansen Marianne M   Giercksky Karl-Erik KE   Ree Anne Hansen AH  

International journal of radiation oncology, biology, physics 20100802 2


Tumor response of rectal cancer to preoperative chemoradiotherapy (CRT) varies considerably. In experimental tumor models and clinical radiotherapy, activity of particular subsets of kinase signaling pathways seems to predict radiation response. This study aimed to determine whether tumor kinase activity profiles might predict tumor response to preoperative CRT in locally advanced rectal cancer (LARC).Sixty-seven LARC patients were treated with a CRT regimen consisting of radiotherapy, fluoroura  ...[more]

Publication: 1/2

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