Transcriptomics

Dataset Information

3

Transcription profiling of human blood from patients with acute and chronic infection with the geohelminth ascaris lumbricoides


ABSTRACT: to compare host gene expression during acute and chronic infection with the geohelminth ascaris lumbricoides

ORGANISM(S): Homo sapiens  

DISEASE(S): Acute Infection With Geohelminth Ascaris Lumbricoides,Chronic Infection With Geohelminth Ascaris Lumbricoides,Healthy

SUBMITTER: Fernanda Schreiber  

PROVIDER: E-TABM-938 | ArrayExpress | 2012-08-31

REPOSITORIES: ArrayExpress

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Publications

Effects of chronic ascariasis and trichuriasis on cytokine production and gene expression in human blood: a cross-sectional study.

Reina Ortiz Miguel M   Schreiber Fernanda F   Benitez Susana S   Broncano Nely N   Chico Martha E ME   Vaca Maritza M   Alexander Neal N   Lewis David J DJ   Dougan Gordon G   Cooper Philip J PJ  

PLoS neglected tropical diseases 20110607 6


Chronic soil-transmitted helminth (STH) infections are associated with effects on systemic immune responses that could be caused by alterations in immune homeostasis. To investigate this, we measured the impact in children of STH infections on cytokine responses and gene expression in unstimulated blood.Sixty children were classified as having chronic, light, or no STH infections. Peripheral blood mononuclear cells were cultured in medium for 5 days to measure cytokine accumulation. RNA was isol  ...[more]

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