Dataset Information


Transcription profiling by array of mouse wild type and Baf250a delta/delta primary stromal cell cultures

ABSTRACT: Global gene expression profiles of primary Baf250a delta/delta and WT FL-derived stromal cell cultures.

Normalized data files with gene level identifiers are available as additional files on the FTP site for this experiment. Background corrections and normalisations were performed using RMA in NimbleScan 2.5

ORGANISM(S): Mus musculus  

SUBMITTER: Josette-Renée Landry  

PROVIDER: E-TABM-990 | ArrayExpress | 2010-06-05


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A mutant allele of the Swi/Snf member BAF250a determines the pool size of fetal liver hemopoietic stem cell populations.

Krosl Jana J   Mamo Aline A   Chagraoui Jalila J   Wilhelm Brian T BT   Girard Simon S   Louis Isabelle I   Lessard Julie J   Perreault Claude C   Sauvageau Guy G  

Blood 20100603 10

It is believed that hemopoietic stem cells (HSC), which colonize the fetal liver (FL) rapidly, expand to establish a supply of HSCs adequate for maintenance of hemopoiesis throughout life. Accordingly, FL HSCs are actively cycling as opposed to their predominantly quiescent bone marrow counterparts, suggesting that the FL microenvironment provides unique signals that support HSC proliferation and self-renewal. We now report the generation and characterization of mice with a mutant allele of Baf2  ...[more]

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