Transcriptomics

Dataset Information

65

Chromatin immunoprecipitation genome wide binding site identification in yeast


ABSTRACT: Genome Wide Location: binding site identification

INSTRUMENT(S): sonifier, vortex

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: Nicola Rinaldi   Richard Young 

PROVIDER: E-WMIT-1 | ArrayExpress | 2013-01-30

REPOSITORIES: ArrayExpress

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Publications

Characterizing a collective and dynamic component of chromatin immunoprecipitation enrichment profiles in yeast.

Ward Lucas D LD   Wang Junbai J   Bussemaker Harmen J HJ  

BMC genomics 20140619


Recent chromatin immunoprecipitation (ChIP) experiments in fly, mouse, and human have revealed the existence of high-occupancy target (HOT) regions or "hotspots" that show enrichment across many assayed DNA-binding proteins. Similar co-enrichment observed in yeast so far has been treated as artifactual, and has not been fully characterized.Here we reanalyze ChIP data from both array-based and sequencing-based experiments to show that in the yeast S. cerevisiae, the collective enrichment phenomen  ...[more]

Publication: 1/2

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