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E-GEOD-12113

ABSTRACT: Transcription profiling by array of human pancreatic tumours in xenografts to investigate the antitumor activity and molecular effects of the novel Hsp 90 Inhibitor, IPI-504, in pancreatic cancer

OTHER RELATED OMICS DATASETS IN: PRJNA113811

PROVIDER: E-GEOD-12113 | ExpressionAtlas | 2025-01-16

REPOSITORIES: ExpressionAtlas

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Dataset's files

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			Action	DRS
	E-GEOD-12113-analysis-methods.tsv	Tabular
	E-GEOD-12113-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-12113-configuration.xml	Xml
	E-GEOD-12113-percentile-ranks.tsv	Tabular
	E-GEOD-12113-zoomifications-log.tsv	Tabular

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Project description:Antitumor Activity and Molecular Effects of the Novel Hsp 90 Inhibitor, IPI-504, in Pancreatic Cancer

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Antitumor Activity and Molecular Effects of the Novel Hsp 90 Inhibitor, IPI-504, in Pancreatic Cancer

2009-07-15 | GSE12113 | GEO

Transcription profiling by array of human pancreatic tumours in xenografts to investigate the antitumor activity and molecular effects of the novel Hsp 90 Inhibitor, IPI-504, in pancreatic cancer

Project description:Tumors from pancreatic cancer specimens obtained at surgery were used for efficacy testing and biologic analysis. These tumors were s.c. explanted in xenograft models for subsequent treatment experiments. This study aimed to assess the antitumor activity of the Hsp90 inhibitor, IPI-504, in pancreatic cancer and to determine the biological effects of the agent. Experiment Overall Design: Five tumor samples were profiled in treated and untreated with IPI504. Untreated samples were profiled in duplicate. The overall design is to identify differentially expressed genes in IPI504 treated versus untreated.

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E-PROT-27

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Transcriptomic analysis of patient-derived ex vivo models of pancreatic cancer

Project description:The aim of this study is to compare the transcriptomic profiles of various ex vivo models of pancreatic cancer. First, primary tumours and their corresponding xenografts in nude mice were analysed by RNA-seq. Monocultures of pancreatic cancer cells derived from the xenografts were then prepared as 2D monolayers, Matrigel-embedded organoids, spheres in suspension and 3D cultures in self-assembling peptide amphiphile (PA) hydrogels. Seven-day cultures were then analysed by RNA-seq. The results suggest that all ex vivo monocultures retain patient-specific transcriptional profiles, especially cancer stem cell signatures, while being deficient in the expression of stromal components such as the core matrisome. Correlations with the primary tumours were generally higher in PA hydrogels than organoids. Biased gene expression signatures were identified in certain models. This is the first study to explore the transcriptomic signatures of four different ex vivo models matched to their primary tumours of origin.

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Project description:Transcription profiling by array of rat experimental tumours to study the effects of dietary lipids

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Transcellular chaperone signaling is an intercellular stress-response that is distinct from the HSF-1 mediated HSR [RNA-seq]

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