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E-GEOD-13987

ABSTRACT: Transcription profiling of human B lineage chronic lymphocytic leukemia, normal B, and normal T cells treated with rolipram, a PDE4 inhibitor

OTHER RELATED OMICS DATASETS IN: PRJNA112481

PROVIDER: E-GEOD-13987 | ExpressionAtlas | 2025-01-24

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-GEOD-13987-analysis-methods.tsv	Tabular
	E-GEOD-13987-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-13987-configuration.xml	Xml
	E-GEOD-13987-percentile-ranks.tsv	Tabular
	E-GEOD-13987.condensed-sdrf.tsv	Tabular

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Transcription profiling of human B lineage chronic lymphocytic leukemia, normal B, and normal T cells treated with rolipram, a PDE4 inhibitor

Project description:PDE4 inhibitors, which activate cAMP signaling by reducing cAMP catabolism, are known to induce apoptosis in B lineage chronic lymphocytic leukemia (CLL) cells but not normal human T cells. The explanation for such differential sensitivity remains unknown. Here, we report studies contrasting the response to PDE4 inhibitor treatment in CLL cells and normal human T and B cells. Affymetrix gene chip analysis in the three cell populations following treatment with the PDE4 inhibitor rolipram identified a set of up-regulated transcripts with unusually high fold-changes in the CLL samples, several of which are likely part of compensatory negative feedback loops. The high fold-change were due to low basal transcript levels in CLL cells, suggesting that cAMP-mediated signaling may be unusually tightly regulated in this cell type. Experiment Overall Design: Four sets of primary B-CLL, normal B, or normal T cells were each treated with rolipram (20 uM) or vehicle and cultured for 4 hours. RNA was extracted and subjected to GeneChip analaysis.

2009-03-07 | E-GEOD-13987 | biostudies-arrayexpress

Patterns of micro RNA expression characterize stages of human B-cell differentiation

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