Project description:IL-17A and F are critical cytokines in anti-microbial immunity but also contribute to auto-immune pathologies. Recent evidence suggests that they may be differentially produced by T-helper (Th) cells but the underlying mechanisms remain unknown. To address this question, a logical model containing 82 components and 136 regulatory links was developed and calibrated with original flow cytometry data using naive CD4+ T cells in conditions inducing either IL-17A or F. Model analyses led to the identification of the transcription factors NFAT2A, STAT5A and Smad2 as key components explaining the differential expression of IL-17A and IL-17F, with STAT5A controlling IL-17F expression, and an interplay of NFAT2A, STAT5A and Smad2 controlling IL-17A expression.

2021-04-06 | MODEL2101150001 | BioModels

Mus musculus

Project description:Timed induction of 10 transcription factors - ES time series data

| PRJNA122815 | ENA

Saccharomyces cerevisiae

Project description:Binding data for nine transcription factors for S. cerevisiae salt response

| PRJNA115641 | ENA

Homo sapiens

Project description:Expression data from a new FACS approach isolated hESC derived endoderm cells using transcription factors

| PRJNA130133 | ENA

Homo sapiens

Project description:Transcription factors enriched in tumor-associated enhancers in VHL-deficient ccRCC