Project description:CaGAL102 is a sequence homolog of Rmlb. In Candida knock out of this gene causes abnormal hyphal morphogenesis and increased sensitivity to cell wall damaging agents. The knock out strain is also avirulent in mouse model of systemic infection. To get a larger insight into the function of the protein product of this gene we carried out global transcription analysis through micro array experiment. The gene is expressed under normal growth conditions and the knock out causes the cells to become hyphal under these conditions. Many of the cell wall proteins were upregulated recapitulating the cell morphology. Keywords: Candida albicans, Gene knockout, genome wide transcription profiling study

2011-03-15 | GSE20883 | GEO

Escherichia coli

Project description:aerobic knock-out

| PRJNA90251 | ENA

Escherichia coli

Project description:anaerobic knock-out

| PRJNA90253 | ENA

Single cell RNASeq of whole mouse kidneys from Uromodulin/Tamm horsfall protein knock-out mice

Project description:Single cell RNASeq of whole mouse kidneys from Uromodulin/Tamm horsfall protein knock-out mice

| PRJNA720395 | ENA

Saccharomyces cerevisiae

Project description:Effect of adk1 knock-out mutation on global transcription