Unknown,Multiomics

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8

Profiling gene expression in Vax2 knockout compared with wild type mice

ABSTRACT: Total RNA samples from Vax2 knockout mouse eyes (at least two biological replicates) were profiled by gene expression. As control we used total RNA from wild type eyes. The analysis was carried out at five different developmental stages: E10.5, E12.5, E16.5, P8, and P60. Keywords: gene expression array-based (RNA / in situ oligonucleotide) Vax2 knockout mouse animal model analyzed at various developmental stages.

OTHER RELATED OMICS DATASETS IN: PRJNA122583

PROVIDER: E-GEOD-19626 | ExpressionAtlas | 2015-09-08

REPOSITORIES: ExpressionAtlas

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Vax2 regulates retinoic acid distribution and cone opsin expression in the vertebrate eye.

Alfano Giovanna G   Conte Ivan I   Caramico Tiziana T   Avellino Raffaella R   Arnò Benedetta B   Pizzo Maria Teresa MT   Tanimoto Naoyuki N   Beck Susanne C SC   Huber Gesine G   Dollé Pascal P   Seeliger Mathias W MW   Banfi Sandro S  

Development (Cambridge, England) 20101209 2

Vax2 is an eye-specific homeobox gene, the inactivation of which in mouse leads to alterations in the establishment of a proper dorsoventral eye axis during embryonic development. To dissect the molecular pathways in which Vax2 is involved, we performed a transcriptome analysis of Vax2(-/-) mice throughout the main stages of eye development. We found that some of the enzymes involved in retinoic acid (RA) metabolism in the eye show significant variations of their expression levels in mutant mice  ...[more]

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