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E-GEOD-22035

ABSTRACT: Transcription profiling by array of human estrogen receptor alpha positive breast tumors with and without PIK3CA mutations.

OTHER RELATED OMICS DATASETS IN: PRJNA128895

PROVIDER: E-GEOD-22035 | ExpressionAtlas | 2025-01-24

REPOSITORIES: ExpressionAtlas

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Dataset's files

Source:

			Action	DRS
	E-GEOD-22035-analysis-methods.tsv	Tabular
	E-GEOD-22035-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-22035-configuration.xml	Xml
	E-GEOD-22035-percentile-ranks.tsv	Tabular
	E-GEOD-22035.condensed-sdrf.tsv	Tabular

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Transcription profiling by array of human estrogen receptor alpha positive breast tumors with and without PIK3CA mutations.

Project description:PI3K/AKT pathway plays one of pivotal roles in breast cancer development and maintenance. PIK3CA, coding PIK3 catalytic subunit, is the oncogene which shows the high frequency of gain-of-function mutations leading to the PI3K/AKT pathway activation in breast cancer. In particular in the ERα-positive breast tumors PIK3CA mutations have been observed in 30% to 40%. However, genes expressed in connection to the pathway activation in breast tumorigenesis remain largely unknown. To identify downstream relevant target genes (and signaling pathways) turned on by the aberrant PI3K/AKT signal in breast tumors, we analyzed gene expression by pangenomic oligonucleotide microarray in a series of 43 ERα-positive tumors with and without PIK3CA mutations. 43 ERα-positive breast tumors including 14 tumors with PIK3CA mutations and 29 tumors without PIK3CA mutattions were used as screening set for microarray.

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