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E-GEOD-22073

ABSTRACT: Testis samples from Alkbh1 wild-type and KO mice

OTHER RELATED OMICS DATASETS IN: PRJNA128951PRJNA158427

PROVIDER: E-GEOD-22073 | ExpressionAtlas | 2015-09-15

REPOSITORIES: ExpressionAtlas

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Dataset's files

Source:

			Action	DRS
	E-GEOD-22073-analysis-methods.tsv	Tabular
	E-GEOD-22073-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-22073-configuration.xml	Xml
	E-GEOD-22073-percentile-ranks.tsv	Tabular
	E-GEOD-22073.condensed-sdrf.tsv	Tabular

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Testis samples from Alkbh1 wild-type and KO mice

Project description:The aim of the study was to elucidate the role of Alkbh1 by targeted deletion in C57/BL6 mice. Alkb deficiency results in sex-ratio distortion of offspring and apoptosis in adult testes, most likely caused by defects in the pachytene stage during spermatogenesis. Due to the pivotal role of Alkbh1 in mouse survival and potentially in germ cells, we searched for Alkbh1-regulated genes in adult testes. Testes from 12 week old mice were selected for RNA extraction and hybridization on Affymetrix microarrays. We used testes from 3 wild type mice and 3 KO mice

2010-06-08 | E-GEOD-22073 | biostudies-arrayexpress

E-GEOD-2259

Project description:Transcription profiling of testis from Sertoli cell-selective androgen receptor knockout mice and wild type mice to unravel the molecular mechanisms mediating the effects of androgens on spermatogenesis

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